I have used my pontoon mostly in the West on extended vacations, but have floated the West Branch some.
Mine is framed and has a platform I can stand-up on. That lets me see rising fish better than from a seated position. If you intend to fish from the pontoon, a good anchor system is invaluable, it needs to hold the pontoon in a decent flow and must be reasonably easy to drop and weigh (or you won't use it, or will delay and miss an opportunity).
I always take more gear than I will need, including an extra rod or two (one rigged for nymphs and one for dries is my starting position). It goes without saying that water and a flashlight are included. On most of the Delaware, it is not that big a deal if you end up floating in the dark, but you do risk feeling like a 14 year-old playing Tom Sawyer. You are really unlikely to get into much trouble unless you are attempting a float in high water (and if that is the case, the float should not take too long). Don't forget the live vest, especially if you are alone. Take the air pump along and some patches, you may never need them, but it might prevent having to drag the pontoon a couple miles to get out.
Inflatable pontoons are rather cumbersome and slow to row. They do not glide smoothly in dead water like a canoe might and rowing downstream into a headwind can be very slow going. I once used mine on Androscoggin in NH and could not finish a drift that I was told was a very comfortable half-day float in a canoe. While there was some fast water, much of it was slow pools with little flow rate. It was only that the river parallels the road that let me get out just before dark and drag the pontoon up, else I probably would have arrived at the takeout at 3 AM. Start with a short trip, maybe Hancock to Stockport to get a feeling for it.